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Oregon Urology Institute Radiation Center is proud to offer advanced prostate cancer patients PROVENGE® (sipuleucel-T), the only personalized treatment that is clinically proven to extend life in certain men with advanced prostate cancer. PROVENGE is an immunotherapy that takes your own immune cells and reprograms them to target and attack your prostate cancer.


PROVENGE is a personalized treatment that reprograms your own immune cells to attack cancer.

It is given over the course of time in three doses. To make each dose, your immune cells, or T-cells, will be collected through apheresis. During apheresis, your blood is drawn and passes through a machine that collects some of your immune cells. The rest of your blood is returned to your body. Apheresis takes three to four hours.

Once your cells are collected, they are sent to a lab where they are reprogrammed into PROVENGE®. The cancer-fighting dose is given by infusion about three days after your cell collection.

Because PROVENGE® is made from your own cells, side effects are typically mild and only last one or two days.



Usually, patients experience few or no side effects when taking PROVENGE. The most common side effects are chills, back pain, joint ache, fatigue, nausea, headache and fever. Usually, they only last one or two days after your infusion.
Most patients can continue working during and resume all or some of their normal daily activities during treatment.
Talk with members of your oncology team about side effects you may experience. They can help you manage negative effects and may prescribe medicines to help provide relief.

  • INDICATION PROVENGE® (sipuleucel-T) is approved by the FDA as an autologous cellular immunotherapy for the treatment of asymptomatic or minimally symptomatic metastatic castrate resistant (hormone refractory) prostate cancer.
    PROVENGE® is made from your own immune cells. Your cells will be collected at a cell collection center approximately 3 days before each scheduled infusion of PROVENGE. There can be risks associated with the cell collection process, which you should discuss with your doctor before deciding to begin treatment with PROVENGE.
  • The most common side effects reported with PROVENGE® were chills, fatigue, fever, back pain, nausea, joint ache, and headache. These are not all the possible side effects of PROVENGE® treatment. For more information, talk with your doctor. Tell your doctor about all your medical problems including heart problems, lung problems or a history of stroke.
  • Tell your doctor right away if you get a fever over 100°F, or redness at the cell collection or infusion sites, because any of these may be signs of infection. Tell your doctor about all the medicines you take, including prescription and nonprescription drugs, vitamins, and dietary supplements.
  • PROVENGE® can cause serious reactions. In controlled clinical trials for the treatment of prostate cancer, serious reactions reported in patients in the PROVENGE® group included reactions resulting from the infusion of the drug, which occurred within 1 day of infusion, and strokes. Severe infusion reactions included chills, fever, fatigue, weakness, breathing problems (shortness of breath, decreased oxygen level, and wheezing), dizziness, headache, high blood pressure, muscle ache, nausea, and vomiting. Tell your doctor right away if you have breathing problems, chest pains, racing heart or irregular heartbeats, dizziness, nausea, or vomiting after getting PROVENGE® because any of these may be signs of heart or lung problems.



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